Expression of cyclooxygenase-2 in bone marrow cells of chronic leukemia and its significance / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 923-926, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-276791
ABSTRACT
The study was aimed to investigate the expression of COX-2 in bone marrow cells of chronic leukemia patients and its potential pathogenetic implications. Western blot was applied for detecting COX-2 expression levels in bone marrow cells of 67 chronic leukemia patients and beta-actin expression levels. Bone marrow aspirations from 14 healthy donors were used as negative controls. The results showed that the positive rates of COX-2 in chronic-phase group of chronic myeloid leukemia (CML-CP) and in group of chronic lymphocytic leukemia (CLL) were 76.32% (29/38) and 75.86% (22/29) respectively. Both CML-CP and CLL group showed a higher expression than control group (p = 0.0000, p = 0.0000 respectively). The expression of LDH in Cox-2 positive group was higher than that in Cox-2 negative group, and the difference between the two groups was statistically significant (p < 0.001). It is concluded that the expression of COX-2 protein can be detected in bone marrow cells of CML-CP and CLL and the expression level of LDH were higher in cells of CML-CP and CLL. The expression of COX-2 may be correlated with prognosis of CML-CP and CLL.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bone Marrow Cells
/
Leukemia, Lymphocytic, Chronic, B-Cell
/
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
/
Gene Expression
/
Cyclooxygenase 2
/
L-Lactate Dehydrogenase
/
Metabolism
Limits:
Adult
/
Aged
/
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2007
Type:
Article
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