Connexin 43 expression and interacellular communicating function in acute leukemia bone marrow stroma cells / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 679-682, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-276845
ABSTRACT
This study was purposed to investigate the connexin 43 (Cx43) expression level in acute leukemia bone marrow stromal cells (ABMSCs) and normal bone marrow stromal cells (NBMSCs), and to explore the difference in communicating functions between these cells. The Cx43 expression levels of ABMSCs and NBMSCs were detected by using immunohistochemistry and computer gray scale assay, and the difference of gap junction intercellular communication (GJIC) was examined through dry transfer technique. The results showed that expression level of Cx43 in ABMSCs was lower than that in NBMSCs and its function of GJIC in ABMSCs was also weaker than that in NBMSCs. It is concluded that cell-cell communication function is lowered in ABMSCs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Physiology
/
Bone Marrow Cells
/
Tumor Cells, Cultured
/
Leukemia
/
Cell Communication
/
Acute Disease
/
Stromal Cells
/
Gap Junctions
/
Connexin 43
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2007
Type:
Article
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