Nucleophosmin mutations in hematological malignancies - review / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 662-666, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-276849
ABSTRACT
Nucleophosmin (NPM) is a protein that shuttles between the nucleus, nucleoplasm and cytoplasm. NPM gene mutations and aberrant cytoplasmic NPM localization have been recently described in acute myelogenous leukemia (AML) with normal karyotype and in a few myelodysplastic syndromes. Expression of NPM mutant reduces the ability of Arf to initiate a p53 response and to induce cell cycle arrest. Clinical research has revealed that NPM mutations are relative to prognosis and can be used to monitor and quantify minimal residual disease (MRD) in AML patients with normal karyotype, therefore, these findings indicate that nucleophosmin mutations might contribute to illustration of myeloid leukemogenesis. In this paper, the research progress of nucleophosmin mutations in haematological malignancies was reviewed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Nuclear Proteins
/
Cell Nucleolus
/
Hematologic Neoplasms
/
Fms-Like Tyrosine Kinase 3
/
Genetics
/
Metabolism
/
Mutation
Type of study:
Prognostic study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2007
Type:
Article
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