A novel thioredoxin reductase inhibitor inhibits cell growth and induces apoptosis in HL-60 and K562 cells / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B
;
(12): 16-21, 2008.
Article
in English
| WPRIM
| ID: wpr-277316
ABSTRACT
Human thioredoxin reductase (TrxR) system is associated with cancer cell growth and anti-apoptosis process. Effects of 1,2-[bis(1,2-benzisoselenazolone-3(2H)-ketone)]ethane (BBSKE), a novel TrxR inhibitor, were investigated on human leukemia cell lines HL-60 and K562. BBSKE treatment induced cell growth inhibition and apoptosis in both cell lines. Apoptosis induced by BBSKE is through Bcl-2/Bax and caspase-3 pathways. Ehrlich's ascites carcinoma-bearing mice were used to investigate the anti-tumor effect of BBSKE in vivo. Tumor-bearing mice treated with BBSKE showed an increase of life span with a comparable effect to cyclophosphamide (CTX). These results suggest a potential usage of BBSKE as a therapeutic agent against non-solid tumors.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Physiology
/
Thioredoxin-Disulfide Reductase
/
Organoselenium Compounds
/
Apoptosis
/
HL-60 Cells
/
Bridged Bicyclo Compounds, Heterocyclic
/
Proto-Oncogene Proteins c-bcl-2
/
K562 Cells
/
Cell Proliferation
Limits:
Humans
Language:
English
Journal:
Journal of Zhejiang University. Science. B
Year:
2008
Type:
Article
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