Clinicopathologic manifestation of amiodarone-induced lung injury / 中华病理学杂志
Chinese Journal of Pathology
; (12): 394-397, 2006.
Article
in Zh
| WPRIM
| ID: wpr-277385
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the clinical, pathologic and radiologic features of amiodarone-induced lung injury.</p><p><b>METHODS</b>The clinical, pathologic and radiologic features, including treatment and follow-up information of three cases diagnosed as amiodarone-induced lung injury from October 2004 to October 2005 in the Peking Union Medical College Hospital were reviewed.</p><p><b>RESULTS</b>All the patients were males, with age ranging from 35 to 64 years. The duration of symptoms varied from 20 days to 3 years. All presented with cough. Worsening dyspnea and inspiratory crackles were noted in two patients. Computerized tomography showed bilateral patchy infiltration, ground-glass appearance and accentuation of bronchovascular markings. The most common pathologic manifestations included cellular interstitial pneumonia associated with intra-alveolar collections of macrophages and type II pneumocyte hyperplasia. Some of the macrophages contained finely vacuolated cytoplasm. An organizing pneumonia pattern was seen in one patient.</p><p><b>CONCLUSIONS</b>Amiodarone-induced lung injury has characteristic pathologic features which may provide clues to diagnosis. Correlation with clinical and radiologic findings is also important.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pathology
/
Pulmonary Alveoli
/
Radiation Effects
/
Biopsy
/
Prednisone
/
Tomography, X-Ray Computed
/
Retrospective Studies
/
Follow-Up Studies
/
Lung Diseases, Interstitial
/
Therapeutic Uses
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Humans
/
Male
Language:
Zh
Journal:
Chinese Journal of Pathology
Year:
2006
Type:
Article