Expression and diagnostic application of C4.4A protein in squamous cell carcinoma and adenocarcinoma / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 277-280, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-277421
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the diagnostic utility of C4.4A gene expression in discriminating a squamous cell carcinoma (SCC) from an adenocarcinoma by immunohistochemistry.</p><p><b>METHODS</b>Immunohistochemical staining was performed to detect the expression of C4.4A protein in 157 cases of SCC and 177 cases of adenocarcinoma of various organs.</p><p><b>RESULTS</b>Overall, 141 of 157 cases of SCC strongly expressed C4.4A protein. In contrast, only 8 of 177 adenocarcinomas showed partial or scattered cell expression of C4.4A protein. The statistic difference between the two groups was highly significant (chi(2) = 244.93, P = 0.000), and also when the tumors were stratified according to the degree of differentiation (P = 0.000).</p><p><b>CONCLUSION</b>C4.4A protein expression may serve as a valuable tumor marker in discriminating a squamous cell carcinoma from an adenocarcinoma, and therefore, may greatly facilitate the differential diagnosis of an epithelial malignancy.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Stomach Neoplasms
/
Esophageal Neoplasms
/
Immunohistochemistry
/
Carcinoma, Squamous Cell
/
Colorectal Neoplasms
/
Adenocarcinoma
/
Biomarkers, Tumor
/
Cell Adhesion Molecules
/
Uterine Cervical Neoplasms
/
Diagnosis
Type of study:
Diagnostic study
Limits:
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Pathology
Year:
2006
Type:
Article
Similar
MEDLINE
...
LILACS
LIS