Expression of anaplastic lymphoma kinase and survivin proteins in anaplastic large cell lymphoma and its significance / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 213-217, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-277440
ABSTRACT
<p><b>OBJECTIVE</b>To study the expression of anaplastic lymphoma kinase (ALK) and survivin proteins in anaplastic large cell lymphoma (ALCL) and there clinical significance.</p><p><b>METHODS</b>The morphologic characteristics were studied by routine light microscopy. Immunohistochemical staining for ALK and survivin proteins was performed using LSAB method.</p><p><b>RESULTS</b>ALK protein was positive in 51 cases (63%) and negative in 30 cases (37%) of the 81 cases of ALCL studied. The prognosis of patients with ALK protein expression was better than those without ALK expression (P < 0.05). As for survivin protein, there were various degrees of expression in all the 77 ALCL cases studied. High level of survivin protein expression was observed in 33 cases (42.9%), while low level of expression was seen in 44 cases (57.1%). The expression of survivin protein did not correlate with that of ALK protein (P > 0.05). The survival rate was significantly lower in patients with high survivin protein expression (P < 0.05). In cases with ALK protein expression, the prognosis was less favorable if there was also high co-expression of survivin protein (P < 0.05). In ALK protein negative cases, prognosis did not significantly correlate with the expression of survivin protein (P > 0.05). In addition, multivariate analysis confirmed the prognosis value of ALK protein expression, survivin protein expression and constitutional symptoms.</p><p><b>CONCLUSION</b>Survivin protein expression can serve as an independent prognostic predictor of unfavorable clinical outcome in patients with ALCL, especially when ALK protein is positive.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prognosis
/
Protein-Tyrosine Kinases
/
Immunohistochemistry
/
Biomarkers, Tumor
/
Survival Analysis
/
Multivariate Analysis
/
Follow-Up Studies
/
Receptor Protein-Tyrosine Kinases
/
Lymphoma, Large-Cell, Anaplastic
Type of study:
Observational study
/
Prognostic study
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Pathology
Year:
2006
Type:
Article
Similar
MEDLINE
...
LILACS
LIS