Analysis on the decline of hepatitis C virus RNA in the blood using a mathematical model / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 886-888, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-277649
ABSTRACT
<p><b>OBJECTIVE</b>To establish a mathematical model of hepatitis C virus (HCV) replication and develop a working theory for antiviral therapy in order to understand the dynamics of HCV replication.</p><p><b>METHODS</b>Peripheral blood cells of 4 hepatitis C patients were cultured. Quantities of the HCV were detected every 15 min by real-time PCR. The data were analyzed using SPSS software. A mathematical functional relationship between HCV RNA and the time lapse was established.</p><p><b>RESULTS</b>The quantity of HCV RNA declined and it fell into a mathematical model Y=3E+0.8e(-0.5467x) (r=0.9547). The estimated virion half-life was 45 min on the average.</p><p><b>CONCLUSIONS</b>The decline of HCV RNA in the blood is not of a linear trend and the HCV RNA lasts a longer time although the speed of the decline is faster than that in vivo.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Virology
/
Virus Replication
/
Blood
/
RNA, Viral
/
Nonlinear Dynamics
/
Hepacivirus
/
Viral Load
/
Hepatitis C, Chronic
/
Half-Life
/
Models, Theoretical
Limits:
Adult
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Hepatology
Year:
2007
Type:
Article
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