Disambiguation of Similar Object-Place Paired Associations and the Roles of the Brain Structures in the Medial Temporal Lobe
Experimental Neurobiology
;
: 15-22, 2010.
Article
in English
| WPRIM
| ID: wpr-27768
ABSTRACT
Amnesic patients who have damage in the hippocampus and in associated areas in the medial temporal lobe suffer from remembering specific events that may or may not share similar objects and locations. Computational models, behavioral studies, and physiological findings all suggest that neural circuits in the hippocampus are suitable for representing seemingly similar events as distinctively different individual event memories. This article offers a selective review on this particular function of the hippocampus and its associates areas such as the perirhinal cortex, mostly centering upon lesion studies and physiological studies using animals. We also present recent experimental results showing that the dentate gyrus subfield of the hippocampus and perirhinal cortex are particularly important for discriminating similar paired associates between same objects and different locations, or vice versa.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Temporal Lobe
/
Brain
/
Dentate Gyrus
/
Hippocampus
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Experimental Neurobiology
Year:
2010
Type:
Article
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