Risk Factors for Mortality in Patients with Invasive Mucormycosis
Infection and Chemotherapy
;
: 292-298, 2013.
Article
in English
| WPRIM
| ID: wpr-27776
ABSTRACT
BACKGROUND:
Mucormycosis is an uncommon and life-threatening fungal infection. The clinical predictors of outcome were evaluated in patients with invasive mucormycosis. MATERIALS ANDMETHODS:
We retrospectively reviewed histologically proven cases of invasive mucormycosis in our institution from 1996 to 2012.RESULTS:
A total of 64 patients were analyzed. The median age was 59 years (interquartile range [IQR], 50-67), and 32 patients (50%) were male. The most common underlying diseases were diabetes mellitus (67%), hematologic malignancy (22%), and solid cancer (19%). The most common infection sites were the rhino-orbito-cerebral area (56%) and the lungs (31%). The 180-day all-cause mortality was 33%. Disseminated infection was associated with increased mortality (hazard ratio [HR] 169.74, 95% confidence interval [CI] 6.41 to 4492.64; P = 0.002). Pulmonary infection (HR 0.08, 95% CI 0.01 to 0.66; P = 0.02) and complete surgical removal of infected tissue (HR 0.12, 95% CI 0.02 to 0.64; P = 0.01) were associated with decreased mortality.CONCLUSIONS:
These results suggest that patients with mucormycosis had a lower risk of mortality if they developed a pulmonary infection, rather than a disseminated infection and with complete debridement of infected tissue.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Retrospective Studies
/
Risk Factors
/
Hematologic Neoplasms
/
Debridement
/
Diabetes Mellitus
/
Lung
/
Mucormycosis
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
/
Male
Language:
English
Journal:
Infection and Chemotherapy
Year:
2013
Type:
Article
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