Synthesis and biological evaluation of tetrahydro-beta-carline derivatives / 药学学报
Acta Pharmaceutica Sinica
;
(12): 828-832, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-277770
ABSTRACT
Kinesin spindle protein (KSP/Eg5) is essential for the formation and maintenance of bipolar spindles during mitosis. Inhibition of this protein leads to cell cycle arrest and apoptosis without interfering other microtubule-dependent processes. Therefore, it is a potential target in cancer therapy. Here, a series of tetrahydro-beta-carboline derivatives 5a - k were synthesized as kinesin spindle protein inhibitor. Their structures were confirmed with 1H NMR, ESI-MS and elemental analysis. The synthesized compounds were evaluated for their inhibition of KSP.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Carbolines
/
Molecular Structure
/
Chemistry
/
Kinesins
/
Metabolism
/
Antineoplastic Agents
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2008
Type:
Article
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