Synthesis and 5-HT reuptake inhibition activity of biarylbenzamidine derivatives / 药学学报
Acta Pharmaceutica Sinica
;
(12): 619-625, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-277786
ABSTRACT
A series of biarylbenzamidine analogs were synthesized and tested for their biological activities of inhibiting the reuptake of 5-HT. All of them were new compounds, and their structures were confirmed by 1H NMR and HRMS. Preliminary in vitro pharmacological tests showed that all target compounds exhibited 5-HT reuptake inhibition activity. Among the tested compounds, 5i, 4a and 5m exhibited potent inhibitory activity against 5-HT reuptake in vitro. It is a chance to find a better precursor of SSRIs (selective serotonin reuptake inhibitors) for further optimization of compounds.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Structure-Activity Relationship
/
Benzamidines
/
Serotonin
/
Selective Serotonin Reuptake Inhibitors
/
Rats, Wistar
/
Antidepressive Agents
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2008
Type:
Article
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