Recent progress in the study on antitumor drugs targeting hypoxia-inducible factor-1 / 药学学报
Acta Pharmaceutica Sinica
;
(12): 565-569, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-277795
ABSTRACT
Hypoxia-inducible factor-1 (HIF-1), as a transcription factor, plays an important role in the adaptation to hypoxic microenvironment within tumors. It can induce a series of genes transcription that participate in angiogenesis, glucose metabolism, cell proliferation, and cell migration/invasion. Thus HIF-1 not only allows cancer cells to survive in hypoxic microenvironment, but also makes the tumor more aggressive. Moreover, HIF-1 also induces tumors to acquire resistance to chemo-/radio-therapy, and is related to poor prognosis. HIF-1 emerges gradually as a potential target to develop new antitumor drugs. This paper reviews recent progress in this field.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Transcription, Genetic
/
Amphotericin B
/
Topotecan
/
Sirolimus
/
Echinomycin
/
Hypoxia-Inducible Factor 1
/
Genetics
/
Indazoles
/
Metabolism
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2008
Type:
Article
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