Advances in the study of molecular mechanism of APOBEC3G anti-HIV-1 / 药学学报
Acta Pharmaceutica Sinica
;
(12): 678-682, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-277813
ABSTRACT
Apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3 protein G (APOBEC3G) is part of the innate immune system of host cells and has cytidine deaminase activity. It specifically incorporates into the virion during HIV-1 replication. The incorporation of APOBEC3G needs its interaction with HIV-1 Gag. In the HIV-1 reverse transcription process, APOBEC3G deaminates dC to dU in the first minus strand cDNA, and then induces extensive hypermutation in the viral genome. Besides deamination, APOBEC3G also inhibits HIV-1 by some kinds of non-deamination mechanisms which need to be further elucidated. HIV-1 Vif counteracts the activity of APOBEC3G by an ubiquitin-proteasome-mediated degradation of APOBEC3G. As a broad spectrum inhibitor of viruses, APOBEC3G also inhibits various retroviruses, retrotransposons and other viruses like HBV. Upregulating the expression of APOBEC3G or blocking the Vif-mediated degradation of APOBEC3G might be novel strategies to treat HIV-1 infection in the future.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Virus Replication
/
Gene Expression
/
HIV Infections
/
HIV-1
/
Anti-HIV Agents
/
Amino Acid Substitution
/
Cytidine Deaminase
/
Vif Gene Products, Human Immunodeficiency Virus
/
APOBEC-3G Deaminase
Limits:
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2008
Type:
Article
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