Synthesis and antitumor activities of triazacyclodecane and its platinum (II) complex / 药学学报
Acta Pharmaceutica Sinica
;
(12): 490-494, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-277825
ABSTRACT
To search for potential antitumor drugs with potent efficiency and low toxicity, a novel 1,4,7-triazacyclodecane and its platinum (II) complex were synthesized. These compounds were characterized by elemental analysis, IR, 1H NMR, 13C NMR, MS spectra, thermoanalysis and conductivity measurement. Antitumor activity study indicated these compounds had strong antitumor activity in vitro to some extent. Inhibition of human liver tumor of CA was examined by antitumor rate and growth rate, complex C showed inhibition activity on transplanting-tumor growth of CA, 12 mg x kg(-1) was as potent as cisplatin, its ID50 was 853.6 mg x kg(-1).
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Organoplatinum Compounds
/
Pathology
/
Pharmacology
/
Drug Screening Assays, Antitumor
/
Random Allocation
/
Chemistry
/
Inhibitory Concentration 50
/
Cell Line, Tumor
/
Cell Proliferation
/
Liver Neoplasms
Type of study:
Controlled clinical trial
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2008
Type:
Article
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