Signal transduction by protein tyrosine kinases and antitumor agents / 药学学报
Acta Pharmaceutica Sinica
;
(12): 323-334, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-277853
ABSTRACT
Intracellular signal transduction plays an important role in the process of cellular metabolism, segmentation, differentiation, biological behaviour and cell death. Overactive signal transduction relates to tumor development and progression. Signaling pathways operated by protein tyrosine kinases (PTKs) will be illuminated here briefly. The Ras/Raf/MAPK and PI-3K/Akt pathways through receptor protein tyrosine kinases (RTKs), the Src, Bcr-Abl and JAK/STAT pathways by non-receptor protein tyrosine kinases (nrPTKs) are shown separately. Antitumor agents targeting the key proteins involved in the above five signalling routes are also summarized in this review.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Protein-Tyrosine Kinases
/
Signal Transduction
/
Receptor Protein-Tyrosine Kinases
/
Ras Proteins
/
Src-Family Kinases
/
Phosphatidylinositol 3-Kinases
/
STAT Transcription Factors
/
Metabolism
/
Antineoplastic Agents
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2008
Type:
Article
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