Research Advances in Resistance to Platinum-based Chemotherapy in Lung Cancer / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 150-155, 2017.
Article
in English
| WPRIM
| ID: wpr-277884
ABSTRACT
Platinum-based chemotherapy is the the cornerstone of treatment of many cancers. Combinations of platinum drugs with other agents are still the mainstream therapies for non-small cell lung cancer,showing significant effectiveness in an early phase. Along with the treatment,the tumor cells can become resistant to chemotherapy drugs,which affect the efficacy and prognosis. The mechanisms of drug resistance are complicated,including abnormal expressions of membrane proteins,enhanced DNA repair functions,abnormal regulation mechanisms of apoptosis,and enhanced cellular detoxification function. In this article we summarize some of the main mechanisms of platinum resistance in lung cancer cells,with an attempt to identify new potential target analogues or inhibitors and improve the efficacies of the combined use of platinum-based drugs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Platinum
/
Prognosis
/
Carcinoma, Non-Small-Cell Lung
/
Drug Resistance, Neoplasm
/
Drug Therapy
/
Lung Neoplasms
/
Antineoplastic Agents
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Acta Academiae Medicinae Sinicae
Year:
2017
Type:
Article
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