Advances in the Relationship between Adipokines and β-cell Failure in Type 2 Diabetes Mellitus / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 601-606, 2016.
Article
in English
| WPRIM
| ID: wpr-277933
ABSTRACT
β-cell failure coupled with insulin resistance plays a key role in the development of type 2 diabetes mellitus (T2DM). Changed adipokines in circulating level form a remarkable link between obesity and both β-cell failure and insulin resistance. Some adipokines have beneficial effects,whereas others have detrimental properties. The overall contribution of adipokines to β-cell failure mainly depends on the interactions among adipokines. This article reviews the role of individual adipokines such as leptin,adiponectin,and resistin in the function,proliferation,death,and failure of β-cells. Future studies focusing on the combined effects of adipokines on β-cells failure may provide new insights in the treatment of T2DM.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Insulin Resistance
/
Leptin
/
Diabetes Mellitus, Type 2
/
Insulin-Secreting Cells
/
Adiponectin
/
Resistin
/
Adipokines
/
Metabolism
/
Obesity
Limits:
Humans
Language:
English
Journal:
Acta Academiae Medicinae Sinicae
Year:
2016
Type:
Article
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