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Research Advances in the Mutation of TET2 Gene in Myeloid Maligancies / 中国医学科学院学报
Acta Academiae Medicinae Sinicae ; (6): 583-588, 2016.
Article in English | WPRIM | ID: wpr-277936
ABSTRACT
TET2 gene is a member of TET oncogene family. It has been reported as a tumor suppressor gene with important roles in myelopiesis. Recent studies have shown that TET2 protein takes part in demethylation by converting 5-methylcytosine (5-mc) into 5-hydroxymethylcytosine (5-hmc). Somatic TET2 inactivation leads to abnormal myelopiesis and myeloid malignancies. In this review,the structure and function of TET2 and the relationship between TET gene mutation and myeloid malignancies are summarized.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Proto-Oncogene Proteins / Hematologic Neoplasms / 5-Methylcytosine / DNA-Binding Proteins / Genetics / Metabolism / Mutation Limits: Humans Language: English Journal: Acta Academiae Medicinae Sinicae Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Proto-Oncogene Proteins / Hematologic Neoplasms / 5-Methylcytosine / DNA-Binding Proteins / Genetics / Metabolism / Mutation Limits: Humans Language: English Journal: Acta Academiae Medicinae Sinicae Year: 2016 Type: Article