Research Advances in Pituitary Adenoma and DNA Methylation / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 475-479, 2016.
Article
in English
| WPRIM
| ID: wpr-277953
ABSTRACT
DNA methylation is closely related to the genesis and development of pituitary adenoma. Studies have shown that high methylation in the promoter region of potassium voltage-gated chanel,shaker related subfamily,beta member 2,O-6-methylguanine-DNA methyltransferase,echinoderm microtubule associated protein like 2 ,ras homolog family member D ,homeobox B1 ,NNAT, and P16 inhibits the expression of these genes and regulates of the proliferation of pituitary adenoma. DNA methylation is also closely related to invasive pituitary adenoma. Therefore,further study on molecular mechanism of DNA methylation of pituitary adenoma will offer a new strategy for the diagnosis and treatment of pituitary adenoma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pituitary Neoplasms
/
Adenoma
/
Gene Expression Regulation, Neoplastic
/
Promoter Regions, Genetic
/
DNA Methylation
/
Genetics
Limits:
Humans
Language:
English
Journal:
Acta Academiae Medicinae Sinicae
Year:
2016
Type:
Article
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