Spatiotemporal Analysis of Retinal Waveform using Independent Component Analysis in Normal and rd/rd Mouse / 의학물리
Korean Journal of Medical Physics
;
: 20-26, 2007.
Article
in Korean
| WPRIM
| ID: wpr-27796
ABSTRACT
It is expected that synaptic construction and electrical characteristics in degenerate retina might be different from those in normal retina. Therefore, we analyzed the retinal waveform recorded with multielectrode array in normal and degenerate retina using principal component analysis (PCA) and independent component analysis (ICA) and compared the results. PCA is a well established method for retinal waveform while ICA has not tried for retinal waveform analysis. We programmed ICA toolbox for spatiotemporal analysis of retinal waveform. In normal mouse, the MEA spatial map shows a single hot spot perfectly matched with PCA-derived ON or OFF ganglion cell response. However in rd/rd mouse, the MEA spatial map shows numerous hot and cold spots whose underlying interactions and mechanisms need further investigation for better understanding.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Retina
/
Retinaldehyde
/
Passive Cutaneous Anaphylaxis
/
Principal Component Analysis
/
Ganglion Cysts
/
Spatio-Temporal Analysis
Limits:
Animals
Language:
Korean
Journal:
Korean Journal of Medical Physics
Year:
2007
Type:
Article
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