Risk factors of hepatorenal syndrome in patients with acute on chronic liver failure / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 743-746, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-277995
ABSTRACT
<p><b>OBJECTIVE</b>To identify the risk factors of hepatorenal syndrome in patients with hepatitis B virus (HBV)-related acute-on-chronic liver failure(ACLF).</p><p><b>METHODS</b>A total of 726 hospitalized patients with HBV-ACLF were retrospectively analyzed. Data of demographic and clinical parameters (sex, age, family history, and presence of liver cirrhosis and diabetes), common complications (spontaneous bacterial peritonitis, pulmonary infection, hepatic encephalopathy, and upper gastrointestinal hemorrhage), and baseline biochemical parameters (albumin, globulin, total bilirubin, direct bilirubin, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, alkaline phosphatase, cholesterol, cholinesterase, K+, Na+, plasma thromboplastin antecedent, alpha-fetoprotein, HBV DNA, white blood cell count, hemoglobin, and platelet count) were collected from the medical records database. Univariate and multiple regression analyses were performed to determine the risk factors of hepatorenal syndrome.</p><p><b>RESULTS</b>Multiple logistic regression analysis indicated that upper gastrointestinal hemorrhage [risk (R) = 1.313, relative hazard (RH) = 3.716, 95% confidence interval (CI) 2.156-6.404], hepatic encephalopathy (R = 1.120, RH = 3.065, 95% CI 1.900-4.945), spontaneous bacterial peritonitis (R = 1.005, RH = 2.733, 95% CI 1.379-5.417), pulmonary infection (R = 1.051, RH = 2.862, 95% CI 1.783-4.592), and white blood cell count (R = 0.056, RH = 1.058, 95% CI 1.010-1.107) were independent risk factors for hepatorenal syndrome development in patients with HBV-ACLF.</p><p><b>CONCLUSION</b>Several risk factors were significantly associated with the development of hepatorenal syndrome in HBV-ACLF, including upper gastrointestinal hemorrhage, hepatic encephalopathy, spontaneous bacterial peritonitis, pulmonary infection, and elevated white blood cell count.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Hepatorenal Syndrome
/
Causality
/
Retrospective Studies
/
Risk Factors
/
Liver Failure
/
Hepatitis B, Chronic
/
End Stage Liver Disease
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hepatology
Year:
2013
Type:
Article
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