Screening by maternal serum markers for Down's syndrome / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 156-159, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-278107
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the optimal method of screening for Down's syndrome (DS) with maternal serum mankers.</p><p><b>METHODS</b>Screening by maternal serum markers for Down's syndrome was offered to all 2886 pregnant women in Peking Union Medical Hospital during 1996.11-2001.3. Alpha-fetoprotein (AFP), human chorionic gonadotrophin (free beta-HCG) were used as markers during the first year of pregnancy. Alpha-fetoprotein, free human chorionic gonadotrophin (HCG) and pregnancy-associated plasma protein A (PAPP-A) were used as mid pregnancy and first-trimester markers in next three years. Amniocentesis and (CVS) were done in those defined as risk cases.</p><p><b>RESULTS</b>The detection rate of Down's syndrome by maternal serum markers was 3.8% (11/2886). The proportion of false positive results in group of triple markers (alpha FP, free beta-HCG, PAPP-A) was 5%.</p><p><b>CONCLUSIONS</b>The PAPP-A was a good marker to detect Down's syndrome in early pregnancy and may be used to predict the outcome during mid trimester of pregnancy. The AFP and free beta-HCG can be useful markers to detect Down's syndrome and fetal abnormality. While prenatal diagnostics can be shifted to an early pregnant period.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pregnancy-Associated Plasma Protein-A
/
Prenatal Diagnosis
/
Blood
/
Biomarkers
/
Alpha-Fetoproteins
/
Mass Screening
/
Down Syndrome
/
Chorionic Gonadotropin, beta Subunit, Human
/
Diagnosis
/
Fetal Diseases
Type of study:
Diagnostic study
/
Prognostic study
/
Screening study
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2003
Type:
Article
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