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Screening by maternal serum markers for Down's syndrome / 中国医学科学院学报
Acta Academiae Medicinae Sinicae ; (6): 156-159, 2003.
Article in Chinese | WPRIM | ID: wpr-278107
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the optimal method of screening for Down's syndrome (DS) with maternal serum mankers.</p><p><b>METHODS</b>Screening by maternal serum markers for Down's syndrome was offered to all 2886 pregnant women in Peking Union Medical Hospital during 1996.11-2001.3. Alpha-fetoprotein (AFP), human chorionic gonadotrophin (free beta-HCG) were used as markers during the first year of pregnancy. Alpha-fetoprotein, free human chorionic gonadotrophin (HCG) and pregnancy-associated plasma protein A (PAPP-A) were used as mid pregnancy and first-trimester markers in next three years. Amniocentesis and (CVS) were done in those defined as risk cases.</p><p><b>RESULTS</b>The detection rate of Down's syndrome by maternal serum markers was 3.8% (11/2886). The proportion of false positive results in group of triple markers (alpha FP, free beta-HCG, PAPP-A) was 5%.</p><p><b>CONCLUSIONS</b>The PAPP-A was a good marker to detect Down's syndrome in early pregnancy and may be used to predict the outcome during mid trimester of pregnancy. The AFP and free beta-HCG can be useful markers to detect Down's syndrome and fetal abnormality. While prenatal diagnostics can be shifted to an early pregnant period.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pregnancy-Associated Plasma Protein-A / Prenatal Diagnosis / Blood / Biomarkers / Alpha-Fetoproteins / Mass Screening / Down Syndrome / Chorionic Gonadotropin, beta Subunit, Human / Diagnosis / Fetal Diseases Type of study: Diagnostic study / Prognostic study / Screening study Limits: Adult / Female / Humans / Pregnancy Language: Chinese Journal: Acta Academiae Medicinae Sinicae Year: 2003 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pregnancy-Associated Plasma Protein-A / Prenatal Diagnosis / Blood / Biomarkers / Alpha-Fetoproteins / Mass Screening / Down Syndrome / Chorionic Gonadotropin, beta Subunit, Human / Diagnosis / Fetal Diseases Type of study: Diagnostic study / Prognostic study / Screening study Limits: Adult / Female / Humans / Pregnancy Language: Chinese Journal: Acta Academiae Medicinae Sinicae Year: 2003 Type: Article