Genotyping of HLA-DRB1 by PCR-SSP in Yunnan Lahu ethnic groups / 中国医学科学院学报

ABSTRACT

<p><b>OBJECTIVE</b>To investigate polymorphism of HLA-DRB1 in Chinese Lahu population in Yunnan.</p><p><b>METHODS</b>Polymerase chain reaction-sequence specific primers (PCR-SSP) were used to determine HLA-DRB1 genotypes of 110 unrelated healthy Lahu minority people of Yunnan Province.</p><p><b>RESULTS</b>Sixteen alleles of DRB1 were detected in this study. The results of test showed that the genotype distributions observed were corresponded with the Hardy-Weinberg equilibrium.</p><p><b>CONCLUSION</b>This study has obtained a more comprehensive and accurate data set of the normal allele frequencies of HLA-DRB1 in Chinese Lahu population in Yunnan Province, which may be of significance in the studies on population genetics and disease association.</p>