Construction of a collagen gel dermis with improved biological property / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 373-376, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-278161
ABSTRACT
<p><b>OBJECTIVE</b>To improve the biological property of artificial skin.</p><p><b>METHODS</b>We have ameliorated Hansburgh and Middelkoop's method of manufacturing artificial dermis. The type I collagenase and Dispase were used to isolated neonate prepuce' dermis fibroblast. The gel dermis was constructed by compounding the fibroblast and collagen swelling solution. The property of the collagen gel dermis was measured.</p><p><b>RESULTS</b>The neonate prepuce's dermis fibroblast had property of high proliferation, high activation of the dermis, and it could secrete abundant extracellular matrix (ECM).</p><p><b>CONCLUSION</b>The collagen gel dermis is an useful dermis substitute.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Cell Separation
/
Cells, Cultured
/
Extracellular Matrix Proteins
/
Skin, Artificial
/
Dermis
/
Cell Biology
/
Collagen Type I
/
Tissue Engineering
/
Fibroblasts
/
Metabolism
Limits:
Humans
/
Male
/
Infant, Newborn
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2002
Type:
Article
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