Synthesis and preliminary studies of O-(2-18F fluoroethyl)-L-tyrosine as a positron emission tomography imaging agent / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 370-372, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-278162
ABSTRACT
<p><b>OBJECTIVE</b>To develop a 18F-labeled amino acid, O-(2-[18F]fluoroethyl) - L-tyrosine(18F-FET), as a positron emission tomography (PET) tracer for imaging cerebral tumors.</p><p><b>METHODS</b>18F-FET was synthesized. Preclinical studies including sterility, endotoxin, and toxicity tests were performed. Two brain tumor cases were studied using 18F-FET and compared with 18F-FDG.</p><p><b>RESULTS</b>Radiochemical purity of 18F-FET was over 95% which remained stable for 6 hours. The 18F-FET injection was sterile and its endotoxin content accorded with the standards of Chinese Pharmacopoeia. The uptake of 18F-FET in the normal brain tissues was significantly lower than that of the tumor, and the images of the brain tumor were clearer than those of 18F-FDG.</p><p><b>CONCLUSION</b>18F-FET can accumulate in the tumor tissues to give high quality images. It suggests that 18F-FET may be a safe and effective tracer for brain tumor imaging.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sarcoma 180
/
Tyrosine
/
Brain Neoplasms
/
Diagnostic Imaging
/
Fluorine Radioisotopes
/
Tomography, Emission-Computed
/
Glioblastoma
/
Fluorodeoxyglucose F18
Type of study:
Diagnostic study
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2002
Type:
Article
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