Design and synthesis of 3'-methyl-furanonucleosides and their anti-tumor activities / 药学学报
Acta Pharmaceutica Sinica
;
(12): 747-753, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-278188
ABSTRACT
Taking 3'-Me-Ado (3'-methyladenosine) and Cladribine as the leading compounds, seventeen 3'-C-methyl-furanonucleosides were designed and synthesized. All the structures were confirmed by 1H NMR and MS. The target compounds were tested in vitro against human pulmonary carcinoma A549, human colon carcinoma LOVO and human leukemia CEM by MTT assay. The results showed that these compounds possessed moderate cytotoxicities.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Drug Screening Assays, Antitumor
/
Molecular Structure
/
Adenosine
/
Cladribine
/
Cell Line, Tumor
/
Antineoplastic Agents
Limits:
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2009
Type:
Article
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