Caenorhabditis elegans: a powerful tool for drug discovery / 药学学报
Acta Pharmaceutica Sinica
;
(12): 687-694, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-278198
ABSTRACT
A simple model organism Caenorhabditis elegans has contributed substantially to the fundamental researches in biology. In an era of functional genomics, nematode worm has been developed into a multi-purpose tool that can be exploited to identify disease-causing or disease-associated genes, validate potential drug targets. This, coupled with its genetic amenability, low cost experimental manipulation and compatibility with high throughput screening in an intact physiological condition, makes the model organism into an effective toolbox for drug discovery. This review shows the unique features of C. elegans, how it can play a valuable role in our understanding of the molecular mechanism of human diseases and finding drug leads in drug development process.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Caenorhabditis elegans
/
Drug Evaluation, Preclinical
/
Drug Discovery
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2009
Type:
Article
Similar
MEDLINE
...
LILACS
LIS