Antifungal active triterpene glycosides from sea cucumber Holothuria scabra / 药学学报
Acta Pharmaceutica Sinica
;
(12): 620-624, 2009.
Article
in English
| WPRIM
| ID: wpr-278209
ABSTRACT
To study the new antifungal active triterpene glycosides of sea cucumber Holothuria scabra. Triterpene glycosides from Holothuria scabra were separated and purified by silica gel chromatography, reversed-phase silica gel chromatography and RP-HPLC. Their structures were elucidated on the basis of spectral data and chemical evidence. Three triterpene glycosides were identified as scabraside A (1), echinoidea A (2) and holothurin A1 (3). Scabraside A (1) is a new triterpene glycoside, and compounds 2 and 3 were isolated from Holothuria scabra for the first time. They showed antifungal activities (1 < or = MIC80 < or = 16 microg mL(-1)).
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Triterpenes
/
Molecular Structure
/
Chemistry
/
Holothuria
/
Glycosides
/
Holothurin
/
Antifungal Agents
Limits:
Animals
Language:
English
Journal:
Acta Pharmaceutica Sinica
Year:
2009
Type:
Article
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