Synthesis and anti-tumor activities of N-substituted benzamide derivatives / 药学学报
Acta Pharmaceutica Sinica
;
(12): 603-608, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-278212
ABSTRACT
To explore novel histone deacetylase (HDACs) inhibitors with anti-tumor activity, MS-275, a HDACs inhibitor, was prepared and used as a lead compound to design new N-substituted benzamide derivatives. MS-275 and eleven target compounds were obtained, and their structures were confirmed by 1H NMR and HR-MS individually. The results showed that the activity of compound 9d was equal to MS-275 in HDACs inhibition tests in vitro and worthy of further investigation. Compound 5c, 5d and 9c displayed obvious dose-effect relationship, which possessed moderate HDACs inhibitory activities. Ten compounds except 9e had selective inhibitory activities on Hut78.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Benzamides
/
Chemistry
/
Cell Line, Tumor
/
Antineoplastic Agents
Limits:
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2009
Type:
Article
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