Pharmacokinetics of rhGH decorated by polyethylene glycol in rat in vivo / 药学学报
Acta Pharmaceutica Sinica
;
(12): 506-509, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-278230
ABSTRACT
To study the pharmacokinetics of rhGH decorated by polyethylene glycol (PEG-rhGH) after sc administration in rat, serum PEG-rhGH concentrations were measured by 125I labeled method after sc in rat, the pharmacokinetic model and parameters were fitted and calculated by the 3P97 program. After sc injection at doses of 150, 300, and 600 microg x kg(-1) in rat, the serum PEG-rhGH concentration-time curves were fitted to a one-compartment model. The rhGH decorated by polyethylene glycol could prolong the action duration of rhGH in vivo, and reach the goal of long-action.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polyethylene Glycols
/
Blood
/
Recombinant Proteins
/
Pharmacokinetics
/
Chemistry
/
Rats, Sprague-Dawley
/
Human Growth Hormone
/
Area Under Curve
/
Delayed-Action Preparations
/
Dose-Response Relationship, Drug
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2009
Type:
Article
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