Synthesis, solubility, lipids-lowering and liver-protection activities of sulfonated formononetin / 药学学报
Acta Pharmaceutica Sinica
;
(12): 386-389, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-278252
ABSTRACT
A water-soluble compound, sodium formononetin-3'-sulfonate with good lipid-lowering and liver-protection activities was synthesized. It was synthesized by sulfonation reaction, and its structure was characterized by IR, NMR and elemental analyses. The solubility of sodium formononetin-3'-sulfonate in water and n-octanol/water partition coefficient were determined by UV spectrophotometry. The lipid-lowering and liver-protection activities of sodium formononetin-3'-sulfonate were tested by using rat's high fat model induce by feeding with high fat food. The results showed that sodium formononetin-3'-sulfonate not only had favorable water, solubility but also had good lipid-lowering and liver-protection activities.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Aspartate Aminotransferases
/
Solubility
/
Triglycerides
/
Blood
/
Molecular Structure
/
Chemistry
/
Adipose Tissue
/
Cholesterol
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2009
Type:
Article
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