Synthesis and antibacterial activity of 7 beta-2-(2-substituted aminothiazol-4-yl)-(Z)-2-methoxyiminoacetylamido-3-quaternaryammoniummethyl-cephalosporins / 药学学报
Acta Pharmaceutica Sinica
; (12): 366-370, 2009.
Article
in Zh
| WPRIM
| ID: wpr-278255
Responsible library:
WPRO
ABSTRACT
In order to find new cephalosporin with more and more potent antibacterial activity, nine new fourth-generation cephalosporins (N1-N9) were synthesized from ethyl 2-(2-aminothiazol-4-yl)-(Z)-2-methoxyiminoacetate (1) via acylation, substitution, hydrolysis, active esterification, condensation and salt formation. The structures of compounds (N1-N9) were confirmed by IR, MS, 1H NMR and elemental analysis. The target compounds possess different antimicrobial activities against Gram-positive and Gram-negative bacteria. The preliminary results of antibacterial activities revealed that they showed better antibacterial activities against Gram-positive bacteria than cefpirome sulfate. In particular, their activities against Staphylococcus aureus and Streptococcus albus are better.
Full text:
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Index:
WPRIM
Main subject:
Pharmacology
/
Staphylococcus aureus
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Streptomyces
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Molecular Structure
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Cephalosporins
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Chemistry
/
Gram-Negative Bacteria
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Gram-Positive Bacteria
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Anti-Bacterial Agents
Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2009
Type:
Article