Hepatobiliary transport of glutathione and its role in cholestasis / 药学学报
Acta Pharmaceutica Sinica
;
(12): 327-332, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-278262
ABSTRACT
Glutathione is a tripeptide comprised by L-glutamate, L-cysteine, and glycine, that serves antioxygenation and deintoxication functions within the cell. Recent study has found that glutathione is the main driving force for bile salt-independent bile flow, impaired biliary excretion of glutathione can lead to cholestasis. This review focuses on hepatobiliary transport of glutathione and its role in cholestasis. Based on the evidence of choleretic effect of glutathione, enhancement of biliary excretion of glutathione may be a good strategy for prevention and treatment of cholestasis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phalloidine
/
Ursodeoxycholic Acid
/
Biological Transport
/
Cholestasis
/
Multidrug Resistance-Associated Proteins
/
Therapeutic Uses
/
Estrogens
/
Genetics
/
Glutathione
/
Jaundice, Chronic Idiopathic
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2009
Type:
Article
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