Comparative pharmacophore analysis of dual dopamine D2/5-HT(2A) receptor antagonists / 药学学报
Acta Pharmaceutica Sinica
;
(12): 314-320, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-278264
ABSTRACT
Dual dopamine D2/5-HT2A receptor antagonists have potent activity and are referred to atypical antipsychotics due to their lower propensity to elicit EPS and their moderate efficacy toward negative symptoms. However, an on-going challenge in developing atypical antipsychotics drugs is to maintain the favorable profiles and avoid of cardiovascular risk. In this paper, comparative pharmacophore analysis of dual dopamine D2/5-HT2A receptor antagonists, hERG K+ channel blockers, and alA adrenoceptor antagonists is carried out, and the results could give some insight into multi-target drug design.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Structure-Activity Relationship
/
Drug Design
/
Molecular Structure
/
Chemistry
/
Drug Delivery Systems
/
Receptors, Dopamine D2
/
Receptors, Adrenergic, alpha-1
/
Receptor, Serotonin, 5-HT2A
/
Ether-A-Go-Go Potassium Channels
/
Adrenergic alpha-1 Receptor Antagonists
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2009
Type:
Article
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