Thoughts and experimental exploration on pharmacokinetic study of herbal medicines with multiple-components and targets / 药学学报
Acta Pharmaceutica Sinica
;
(12): 270-275, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-278271
ABSTRACT
The pharmacokinetic research of traditional Chinese medicines (TMC) is an inalienable part of the chain of TCM modernization and plays an important role in the TCM novel drug development. However, the researching method and system that is consistent with the specific characteristics of TCM, i.e., multiple-components and targets, is still lacking. Furthermore, the current understanding of the critical scientific questions of TCM pharmacokinetics remains still unclear. This review makes a brief summary of our recent developments on the pharmacokinetic exploration of TCMs, mainly including integral pharmacokinetic study of multiple components, herbalome analysis both in vitro and in vivo, mechanism based compatibility study for herbal components interactions, and the representative pharmacokinetic study for single herbal compound. Furthermore, the critical scientific questions of TCM pharmacokinetics are discussed based on understanding the requirements of novel drug developments from TCM.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plants, Medicinal
/
Drugs, Chinese Herbal
/
Pharmacokinetics
/
Chemistry
/
Quantitative Structure-Activity Relationship
/
Principal Component Analysis
/
Drug Combinations
/
Drug Interactions
/
Drug Synergism
/
Medicine, Chinese Traditional
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2009
Type:
Article
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