Transport of aripiprazole across Caco-2 monolayer model / 药学学报
Acta Pharmaceutica Sinica
;
(12): 188-191, 2009.
Article
in English
| WPRIM
| ID: wpr-278282
ABSTRACT
This study aimed to investigate the transport characteristics of aripiprazole. A human intestinal epithelial cell model Caco-2 cell in vitro cultured had been applied to study the transport of aripiprazole. The effects of time, concentration of donor solutions, pH, temperature and P-glycoprotein inhibitor on the transport of aripiprazole were investigated. The determination of aripiprazole was performed by HPLC. It is concluded that aripiprazole is transported through the intestinal mucosa via a passive diffusion mechanism primarily, coexisting with a carrier-mediated transport. The transport of aripiprazole is positively correlated to transport time, pH, and temperature. Papp increased with donor concentrations up to 10 microg x mL(-1), and then decreased for higher concentrations. The P-glycoprotein inhibitor cyclosporine A significantly enhanced the transport amount of aripiprazole.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Piperazines
/
Temperature
/
Time Factors
/
Antipsychotic Agents
/
Biological Transport
/
Pharmacokinetics
/
Cyclosporine
/
Quinolones
/
ATP Binding Cassette Transporter, Subfamily B, Member 1
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Acta Pharmaceutica Sinica
Year:
2009
Type:
Article
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