Effects of COX-2 inhibitor celecoxib on expressions of VEGF, b-FGF and TGF-β mRNA in acute leukemia cells / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1086-1089, 2012.
Article
in Zh
| WPRIM
| ID: wpr-278430
Responsible library:
WPRO
ABSTRACT
This study was aimed to investigate the influence and significance of celecoxib (specific inhibitor of cyclooxygenase-2) on mRNA expressions of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (b-FGF), transforming growth factor β (TGF-β) in acute leukemia cells. The expressions of VEGF, b-FGF, TGF-β mRNA were measured by RT-PCR in acute leukemia cells treated with celecoxib (80 µmol/L, for 48 h) or with PBS. The results showed that the obvious expressions of VEGF, b-FGF, TGF-β mRNA were observed in acute leukemia cells. By using Pearson correlation analysis, there was positive correlation between VEGF mRNA and b-FGF mRNA expressions (r = 0.559, P = 0.001), and negative correlation between VEGF and TGF-β mRNA expressions (r = -0.4, P = 0.029). Expression levels of VEGF, b-FGF, TGF-β mRNA in experimental group were lower than that in control group (P < 0.01). It is concluded that COX-2 inhibitor celecoxib can inhabit vascular endothelial growth through down-regulating the mRNA expression of VEGF, b-FGF and TGF-β in acute leukemia cells. COX-2 inhibitor may offer supplemental effect for treating acute leukemia.
Full text:
1
Index:
WPRIM
Main subject:
Pharmacology
/
Pyrazoles
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Sulfonamides
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RNA, Messenger
/
Signal Transduction
/
Leukemia
/
Fibroblast Growth Factor 2
/
Transforming Growth Factor beta
/
Vascular Endothelial Growth Factor A
/
Drug Therapy
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Zh
Journal:
Journal of Experimental Hematology
Year:
2012
Type:
Article