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Clinical study of intravenous injecting itraconazole as empirical antifungal therapy for patients with hematological malignancies / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 1000-1004, 2012.
Article in Chinese | WPRIM | ID: wpr-278448
Responsible library: WPRO
ABSTRACT
This study was purposed to investigate the efficacy and safety of intravenous injecting itraconazole (ITCZ) as empirical antifungal therapy in the patients with hematological malignancies. According to recommendation in IDSA guidebook, the patients suffered from fever during neutropenia and inefficacy of treatment using broad-spectrum antibiotics for 4 days should receive intravenous injection of ITCZ as empirical antifungal therapy. The results showed that the overall clinical response rate to ITCZ injection was 62.9% (22/35), and the success rate of achieving composite endpoints was 54.3% (19/35). Mild adverse reactions were observed in 6 patients (17.1%). The injection of ITCZ was stopped in 2 patents (5.7%) due to adverse reaction. Further analysis revealed that the response rate was higher in patients with fever prior to the start of ITCZ within five days than beyond five days (P = 0.031). The response rate was higher in patients with possible invasive fungus infection (IFI) than that in patients with probable and confirmed IFI (P = 0.002). The prophylactic antifungal treatment during neutropenia displayed no significant influence on efficacy of empirical antifungal therapy with itraconazole (P = 0.054). It is concluded that the good efficacy and safety of empirical ITCZ injection for hematological malignancies patients is efficient and safe.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Aged / Female / Humans / Male / Adolescent / Treatment Outcome / Itraconazole / Hematologic Neoplasms / Adult / Therapeutic Uses Type of study: Practice guideline Language: Chinese Journal: Journal of Experimental Hematology Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Aged / Female / Humans / Male / Adolescent / Treatment Outcome / Itraconazole / Hematologic Neoplasms / Adult / Therapeutic Uses Type of study: Practice guideline Language: Chinese Journal: Journal of Experimental Hematology Year: 2012 Type: Article