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Expression and significance of HGAL and LMO2 in follicular lymphoma / 中华病理学杂志
Chinese Journal of Pathology ; (12): 83-85, 2016.
Article in Chinese | WPRIM | ID: wpr-278559
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the diagnostic value of HGAL and LMO2 expression and compare with CD10 and bcl-6 in follicular lymphoma (FL).</p><p><b>METHODS</b>63 cases of FL were collected from Guangdong General Hospital. The expression of HGAL, LMO2, CD10 and bcl-6 was assessed by immunohistochemistry.</p><p><b>RESULTS</b>The expression rates of HGAL, LMO2, CD10 and bcl-6 were 98.4% (62/63), 82.5% (52/63), 82.5% (52/63) and 87.3% (55/63), respectively. The expression rate of HGAL was higher than those of LMO2, CD10 and bcl-6, but the differences were not significant (P>0.05). There was no significant difference in HGAL, LMO2 and bcl-6 expression among FL1, FL2 and FL3 cases. The CD10 expression rate of FL1-3A cases was significantly higher than that of FL3B cases(P<0.01).</p><p><b>CONCLUSIONS</b>HGAL and LMO2, especially HGAL, can be used in FL particularly high grade FL as useful germinal center marker.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Immunohistochemistry / Neprilysin / Biomarkers, Tumor / Lymphoma, Follicular / Proto-Oncogene Proteins / Germinal Center / Adaptor Proteins, Signal Transducing / Proto-Oncogene Proteins c-bcl-6 / LIM Domain Proteins / Metabolism Limits: Humans Language: Chinese Journal: Chinese Journal of Pathology Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Immunohistochemistry / Neprilysin / Biomarkers, Tumor / Lymphoma, Follicular / Proto-Oncogene Proteins / Germinal Center / Adaptor Proteins, Signal Transducing / Proto-Oncogene Proteins c-bcl-6 / LIM Domain Proteins / Metabolism Limits: Humans Language: Chinese Journal: Chinese Journal of Pathology Year: 2016 Type: Article