Major role of stromal cell derived factor and its receptor CXCR4 in the mobilization and homing of hematopoietic stem/progenitor cells - review / 中国实验血液学杂志

ABSTRACT

Stromal cell derived factor (SDF), expressing on bone marrow stromal cells is a CXC-type chemokine, which specifically chemoattracts hematopoietic stem cells (HSCs) expressing CXCR4. SDF plays important roles in homing and mobilizing of HSCs. In this paper the regulatory mechanism of SDF/CXCR4 in the HSC migration process is mainly reviewed.