Interleukin-18 and its related cytokines in plasma of patients with idiopathic thrombocytopenic purpura / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 662-664, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-278817
ABSTRACT
To explore the role of immune regulating cytokines in pathogenesis of the idiopathic thrombocytopenic purpura (ITP) and its clinical significance, the levels of IL-18, TNF-alpha and Sc5b-9 in plasma of 32 ITP patients and 18 normal individuals were detected using ELISA methods. The results showed that IL-18, TNF-alpha and sC5b-9 levels in plasma of ITP patients were higher than that in normal individuals. The level of IL-18 was positively correlated with the levels of TNF-alpha and sC5b-9. In conclusion, The rising levels of the IL-18, TNF-alpha and sC5b-9 were correlated with disorder of Th1/Th2 subsets, and may contribute to the immune dysfunction in ITP patients. The dynamic observation of these cytokines may be useful in directing the clinical treatment for ITP patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
Complement Membrane Attack Complex
/
Tumor Necrosis Factor-alpha
/
Purpura, Thrombocytopenic, Idiopathic
/
Interleukin-18
/
Allergy and Immunology
Limits:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2003
Type:
Article
Similar
MEDLINE
...
LILACS
LIS