Analysis of HLA matching probability in Guangzhou Cord Blood Bank / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 424-428, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-278872
ABSTRACT
The HLA matching results for 1 060 patients searching donors within 3 000 units of umbilical cord blood in Guangzhou Cord Blood Bank from 1998 to 2002 were analyzed. There were 119 (11.23%) and 992 (93.58%) patients found 6/6 and more than 4/6 of HLA matched loci of unrelated cord blood donors respectively. 61.29% of probability in all patients could find one or more cord blood with 4/6 or more matched loci and total nucleated cell (TNC) dose of >or= 3.7 x 10(7)/kg. The highest mean body weight in these supplied patients was 79 kg. The probability was 89.79% for those patients with TNC dose of >or= 2.0 x 10(7)/kg and >or= 4/6 of HLA loci matched. In these patients, the highest weight was 175 kg. In conclusion, a cord blood bank with 3 000 units or more of cord blood in stock shows a high probability of HLA matching and can meet the requirement of TNC >or= 3.7 x 10(7)/kg dose in child and part of adult patients. The umbilical cord blood is a good alternative stem cell source for all patients including adults.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Transplantation
/
Blood Banks
/
Body Weight
/
Histocompatibility Testing
/
Probability
/
Hematopoietic Stem Cell Transplantation
/
Fetal Blood
/
Methods
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2003
Type:
Article
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