Clinical features and survival analysis of patients with CD20 positive adult B-lineage acute lymphoblastic leukemia / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 4-9, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-278926
ABSTRACT
<p><b>OBJECTIVE</b>To explore the clinical and survival significance of CD20 positive adult patients with B-lineage acute lymphoblastic leukemia (B-ALL).</p><p><b>METHODS</b>The clinical features and survival of 168 adult patients with B-ALL diagnosed and treated in our department from May 2007 to July 2011 were analyzed retrospectively, 58 expressed CD20 and 110 not.</p><p><b>RESULTS</b>The sex, distribution of age, anemia, thrombocytopenia, infiltration of liver, spleen and lymph nodes, the expression of myeloid lineage marker, incidence of Ph chromosome, complete remission within 4 weeks showed no significant differences in CD20 positive and negative groups (P>0.05); median white blood cell count at diagnosis and the rate of patients with high white blood cell count in CD20 positive group were 19.2×10⁹/L and 37.9% respectively, which were significantly higher than those of 6.93 × 10⁹/L and 20.9% in CD20 negative group (P<0.05); cumulative incidence of relapse between two groups showed significant difference (P<0.05); multivariable analysis for overall survival and progress-free survival identified CD20 positivity as independent predictor.</p><p><b>CONCLUSION</b>The expression of CD20 in adult patients with B-ALL appeared to be associated with high white blood cell count and poor prognosis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Remission Induction
/
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
/
Survival Analysis
/
Retrospective Studies
/
Disease-Free Survival
/
Cell Lineage
/
Antigens, CD20
/
Leukocyte Count
Type of study:
Observational study
Limits:
Adult
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Hematology
Year:
2015
Type:
Article
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