The comparative study of the effects between modified FLAG and CAG on relapsed or refractory acute myeloid leukemia / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 966-969, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-278968
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the efficacy and toxicity of modified FLAG and CAG on relapsed or refractory acute myeloid leukemia (AML).</p><p><b>METHODS</b>Sixty-one patients with relapsed or refractory AML were divided into modified FLAG or CAG group. In modified FLAG group G-CSF 200 μg·m⁻²·d⁻¹ on days 0-5; fludarabine 30 mg·m⁻²·d⁻¹ on days 1-5; Ara-C 1.0 g·m⁻²·d⁻¹ on days 1-5. In CAG group Ara-C 10 mg·m⁻²·12 h⁻¹ on days 1-14, aclarubicin 20 mg/d on days 1-4, G-CSF 200 μg·m⁻²·d⁻¹ on days 0 1-14.</p><p><b>RESULTS</b>The complete response (CR) rate was 43% (12/28) and the partial response (PR) rate 18% (5/28) with the overall response (OR) rate of 61% in modified FLAG group. CR rate was 21% (7/33) and PR rate 15% (5/33) with OR rate of 36% in CAG group. There was significant statistical difference between two groups (P<0.05). The main toxicities of these groups were myelosupression and infection. The infection rate was 68% (19/28) in modified FLAG group (twenty-two patients were treated in the sterile laminar flow ward duing neutropenic period), treatment related mortality (TRM) in modified FLAG group was 7%; The infection rate was 55% (18/33) in CAG group (no patient was treated in the sterile laminar flow ward), TRM in CAG group was 3%. There was no significant statistical difference in two groups (P>0.05).</p><p><b>CONCLUSION</b>Modified FLAG was effective for relapsed or refractory AML. The supportive cares to strengthen infection-controlled measures and shorten the period of bone marrow suppression produced the additional effect. CAG regimen has low adverse reactions and could be individualized to elder or weak patients.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Aclarubicin
/
Leukemia, Myeloid, Acute
/
Antineoplastic Combined Chemotherapy Protocols
/
Granulocyte Colony-Stimulating Factor
/
Cytarabine
/
Therapeutic Uses
/
Drug Therapy
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Hematology
Year:
2014
Type:
Article
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