Histopathology and immunohistochemical study in the classification of lymph node lesions

ABSTRACT

Background: Large lymph-node is clinically common sign. However, in some cases, it is difficult to diagnosis by staining method routinely. Objectives: To classify of lymph node lesions by histopathological and immunohistochemical study. Subjects and methods: 1860 cases carried out lymph node biopsies at K Hospital were histologically and immunohistochemically analyzed. Results: The most common lesions were lymph node metastasis (35.25%) chronic lymphnoditis (20.82%), tuberculous lymphnoditis (19.42%) and non Hodgkin lymphoma (18.62%). Histological typing of metastasis revealed that the most frequent types were undifferentiated carcinomas (28.13%), squamous carcinomas (23.7%), adenocarcinomas (16.97%) and type-unspecified carcinomas (13.3%). Non Hodgkin lymphoma rate was higher than that of Hodgkin lymphoma (86.06% versus 12.8%). Immunopheotype of non Hodgkin lymphomas showed that 79.71 % were B cell type, 18.15% were T cell type and 2.14% were Ki-1 type. The most common types of B cell lymphomas were diffuse large B cell lymphomas (35.57%), follicular lymphomas (25.9%) and diffuse small B cell lymphomas (13.83%), The most common types of T cell lymphomas were lymphoblastic T cell lymphomas (41.8%)., large T cell lymphomas (23.53%) and unspecified periphery T cell lymphomas (11.76%). Conclusion: Immunohistochemical analysis of metastasis allowed identifying immunophenotypes of different types of metastatic carcinoma and melanoma and evaluating the origin of unknown primary metastasis. \r\n', u'\r\n', u'\r\n', u'