Risk factors for multidrug-resistant Klebsiella pneumoniae sepsis in children / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 932-936, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-279022
ABSTRACT
<p><b>OBJECTIVE</b>To explore the risk factors for sepsis caused by multidrug-resistant Klebsiella pneumonia (MDR-KP) and to provide a reference for the prevention of MDR-KP sepsis and rational use of antibiotics.</p><p><b>METHODS</b>A retrospective case-control study of 41 children with MDR-KP sepsis (case group) and 53 pediatric patients without MDR-KP sepsis (control group) between March 2010 and Febrary 2014 was conducted. Multiple logistic regression analysis was performed to estimate the independent risk factors for MDR-KP sepsis.</p><p><b>RESULTS</b>Compared with the control group, the case group had a longer length of stay in the PICU before infection (P<0.05), more prolonged duration of mechanical ventilation before infection (P<0.05), a larger total number of days of mechanical ventilation (P<0.05), more days of antibiotic use before infection (P<0.05), more types of antibiotics used before infection (P<0.05), and a higher mortality (P<0.05). The logistic regression analysis showed that more types of antibiotics used before infection and use of third-generation cephalosporin and carbapenems were independent risk factors for MDR-KP sepsis (P<0.05).</p><p><b>CONCLUSIONS</b>Rational use of antibiotics is an effective measure to prevent MDR-KP sepsis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Klebsiella Infections
/
Case-Control Studies
/
Logistic Models
/
Retrospective Studies
/
Risk Factors
/
Bacteremia
/
Drug Resistance, Multiple, Bacterial
/
Drug Therapy
/
Klebsiella pneumoniae
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2015
Type:
Article
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