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Effects of hemoperfusion treatment on serum IL-23 and IL-17 levels in children with Henoch-Schönlein purpure / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 796-799, 2015.
Article in Chinese | WPRIM | ID: wpr-279050
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of hemoperfusion treatment on serum interleukin-17 (IL-17) and IL-23 levels in children with Henoch-Schönlein purpura (HSP).</p><p><b>METHODS</b>Eighty-seven children who were diagnosed with HSP and who had received hemoperfusion treatment between January 2011 and December 2012 were enrolled. Twenty-seven sex- and age-matched healthy children were recruited as normal controls. Enzyme-linked immunosorbent assay (ELISA) was used to measure serum concentrations of IL-17 and IL-23.</p><p><b>RESULTS</b>The serum IL-23 and IL-17 levels in the HSP group were significantly higher than in the control group (P<0.05). After hemoperfusion treatment, the serum IL-23 and IL-17 levels in the HSP group were significantly reduced to the levels of the control group. Serum serum IL-17 level was positively correlated with serum IL-23 level (P<0.05) in children with HSP.</p><p><b>CONCLUSIONS</b>Hemoperfusion treatment can reduce serum IL-23 and IL-17 levels in children with HSP, suggesting that the treatment may be effective for HSP.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Physiology / IgA Vasculitis / Therapeutics / Blood / Hemoperfusion / Interleukin-17 / Allergy and Immunology / Interleukin-23 Limits: Child / Child, preschool / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Physiology / IgA Vasculitis / Therapeutics / Blood / Hemoperfusion / Interleukin-17 / Allergy and Immunology / Interleukin-23 Limits: Child / Child, preschool / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2015 Type: Article