Association between acanthosis nigricans and metabolic syndrome in children with obesity / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 672-676, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-279077
ABSTRACT
<p><b>OBJECTIVE</b>To investigate adipokines levels in obese children with acanthosis nigricans (AN) and to explore the relationship between AN and metabolic syndrome (MS).</p><p><b>METHODS</b>A cross-sectional study was performed on 109 obese children and 47 age- and gender-matched normal controls. The obese children were divided into two groups with AN and without AN. Serum levels of adiponectin, leptin, TNF-α and retinol-binding protein 4 (RBP4) were measured using ELISA. Multiple logistic regression analysis was performed to estimate the association of clinical parameters with MS.</p><p><b>RESULTS</b>Waist-hip ratio, systolic blood pressure, triglyceride, fasting insulin and insulin resistance index (HOMA-IR) were significantly higher in obese children with AN than in those without AN and normal controls (P<0.05). The obese children with AN and without AN had lower adiponectin levels than normal controls (P<0.05), on the contrary, the obese children with AN had higher leptin levels than those without AN and normal controls (P<0.05). Multiple logistic regression analysis revealed that AN (OR=3.469, 95%CI 1.518-7.929) and BMI (OR=7.108, 95%CI 2.359-21.416) were independent risk factors for MS.</p><p><b>CONCLUSIONS</b>As a visible marker of insulin resistance, AN is associated with abnormal adipokines secretion. Reducing the incidence of AN and losing weight may prevent obesity associated MS.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
Insulin Resistance
/
Logistic Models
/
Cross-Sectional Studies
/
Leptin
/
Metabolic Syndrome
/
Adiponectin
/
Acanthosis Nigricans
/
Obesity
Type of study:
Observational study
/
Prevalence study
/
Prognostic study
/
Risk factors
Limits:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2015
Type:
Article
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