Experimental study on treatment of minimal change nephropathy with Lespedeza michx / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 614-617, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-279098
ABSTRACT
<p><b>OBJECTIVE</b>To study the therapeutic effect of Lespedeza Michx in experimental rat model of minimal change nephropathy (MCN).</p><p><b>METHOD</b>The rat MCN model was reproduced by tail-intravenous injection of Adriamycin. The treatment effect of Lespedeza Michx was determined by the detection of urine protein collection for 24 hours, malondialdehyde (MDA), superoxide dismutase (SOD), ATCO, IL-8, TNF-alpha in serum, and renal histopathological changes were observed by microscope.</p><p><b>RESULT</b>Lespedeza Michx could decrease the contents of urine proteinuria, MDA, IL-8, and TNF-alpha in serum, increase SOD level and improved the pathological change of glomeruli.</p><p><b>CONCLUSION</b>Lespedeza Michx was effective on MCN.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Superoxide Dismutase
/
Flavonoids
/
Blood
/
Doxorubicin
/
Random Allocation
/
Chemistry
/
Interleukin-8
/
Tumor Necrosis Factor-alpha
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2005
Type:
Article
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